In the context, it is mentioned that comedian was so ( some negative word ) as to be unable to some basic word, understand ) the effect she had on others and her audience. The audience quickly stood up to leave, hoping their action would send a message. So, the answers that will match this context will be Oblivious, Discern, send an ambiguous message.

answers are revealed in the question, please fix.

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Here is the breakdown of the correct answers for each blank.

Blank (i): oblivious
The phrase "was not lost on her audience" indicates a contrast. The audience was aware of something that the comedian was not. The only word that fits this context is oblivious, meaning unaware of or not concerned about what is happening.

Blank (ii): discern
The second blank needs a word that describes what the comedian was unable to do regarding the audience's reaction. Discern, meaning to perceive or recognize something, fits perfectly. The comedian was unable to "discern" or recognize the effect she was having on them.

Blank (iii): send an unambiguous message
The audience's action of standing up to leave was intended to be a clear signal to the comedian. The phrase send an unambiguous message precisely captures this intention. The audience's departure was not a subtle hint; it was a direct, clear communication that the comedian's performance was not going well.

Complete Sentence:
That the comedian was so oblivious as to be unable to discern the effect she had on others was not lost on her audience, who quickly stood up to leave, hoping their action would at last send an unambiguous message.