OE


Begin by considering the three "hard and fast conditions" - the digits and the one upper-case letter. For the first number, you will have 10 choices and for the second 9 (since you cannot repeat). For the captial letter, you have 26 choices. Thus far, your password has 10 * 9 * 26 possible combinations.
Now, given your remaining options, you have 8 digits, 25 upper-case letters, and 26 lower-case letters (i.e. 59 possible choices). Since you cannot repeat, you will thus have for your remaining choices 59, 58, and 57 possibilities.
Putting all of this together, you have: 10 * 9* 26 *59 * 58 *57 or 456426360 choices.