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The opening phrase “It is in no way shocking that” suggests that whatever follows will at first appear to be “shocking.” The second part of the sentence provides another clue when it says “however” other scientists must be able to “duplicate the normal pattern” of the original experiment in order to consider its results valid. So the blank must be filled by a word that describes results that deviate from what is expected, such as the correct answer “anomalies.” Although “anxiety” and “malfunctions” might be unexpected outcomes of scientific experiments, they do not fit with the second part of the sentence and so are not correct. “Vaccines” and “paradigms,” or models, are expected outcomes of scientific experiments and so cannot be correct either.