A. **Hamstring:** This option is fitting in the context. "Hamstring" means to cripple or impede, and in this context, it conveys the idea that individuals, governments, and companies hinder themselves by rigidly following goals even when conditions change drastically.

B. **Reinvent:** This option is also suitable. "Reinvent" means to change something so much that it appears entirely new, and in the context of setting goals based on current conditions, it implies the ability to adapt and transform in response to changing circumstances.

C. **Promote:** This option does not fit the context well. "Promote" means to support or encourage, and it doesn't capture the idea of hindering oneself by rigidly adhering to goals despite changing conditions.

D. **Revitalize:** This option is not the best fit. "Revitalize" means to bring something back to life or restore its vitality, and it doesn't convey the idea of blindly following goals without adapting to changing conditions.

E. **Impair:** This option is fitting. "Impair" means to weaken or damage, and in the context, it suggests that individuals, governments, and companies weaken themselves by persistently following goals even when conditions undergo drastic changes.

F. **Invigorate:** This option is not suitable. "Invigorate" means to give strength or energy, which contrasts with the idea of hindering oneself due to inflexibility in goal-setting.

So, A. **Hamstring** and E. **Impair** both work in the given context, emphasizing the negative consequences of sticking to goals without adapting to changing conditions.

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